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Regeneration of ovaries and endometrium

Regeneration of ovarian structures

One of the main challenges for modern reproductive medicine is the treatment of infertility in patients with reduced or depleted ovarian reserve. The problem is that there are no effective therapies to increase ovarian activity in this group of patients, and egg donation is considered the only proven treatment approach. Nowadays, however, we can observe important progress in the development of methods for preserving the reproductive capacity of women, which include cryopreservation of eggs, embryos and ovarian tissue. In addition, new methods known as in vitro activation of dormant follicles, as well as the use of stem cells to regenerate ovarian structures, should be mentioned.

They are based on specific methods of extracting stem cells and / or active substances and growth factors from the patient’s circulatory system. This approach has a positive effect on fibrosis – a hallmark of the aging ovary.
Treatment causes activation of angiogenesis, control of inflammation, increased anabolism, cell migration, differentiation and proliferation, and limits the processes of programmed cell death (apoptosis).

The method was developed by a team of researchers at Harvard University who injected mouse ovaries with growth factors, as a result of which mature ova are formed from ovarian stem cells.

In clinical practice, this innovative therapy is usually offered to patients with reduced or depleted ovarian reserve and to women over the age of 43 who want to become pregnant using their own eggs. This treatment is also recommended in cases of a series of unsuccessful in vitro procedures in which pregnancy is not achieved with the patient’s own eggs. If ovarian regeneration therapy is successful, the patient can become pregnant naturally or by other methods of infertility treatment, such as intrauterine insemination or in vitro technology.

What is the treatment?

Before planning the procedure for regeneration of the function of the ovarian structures, the patient undergoes the necessary gynecological examinations and hormonal tests. The ovarian reserve is determined on the basis of a set of criteria. Following is the planning and implementation of the procedure according to a certain algorithm for treatment. A day and time are appointed for the manipulation, before which venous blood is taken from the patient. It takes between 2 and 4 hours to process. This is followed by injection of isolated and activated growth factors into the cortical structures of the ovarian tissue. This is done with the help of anesthesia and under ultrasound control. The effect of the procedure is established 6-12 weeks later, lasting from 5 to 8 months. The first symptoms of exposure are expressed in the regulation of the menstrual cycle, increased sexual desire and activity, improving the quality of eggs and embryos found in an in vitro procedure. The results of studies show that after applying the procedure of ovarian regeneration, the success of the method (expressed in childbirth) depends on the condition of the ovary and the age of the patient, respectively in women with unsatisfactory ovarian response success rate is about 27%, women with premature failure. of ovarian function – 10%, perimenopausal women – 17% and for menopausal women – 3%.
There are no contraindications for the use of this treatment, and the risks are minimal and similar to those of the in vitro procedure.

Endometrial regeneration

The endometrium plays an important role in achieving optimal results in Assisted Reproductive Technologies. Studies have shown that insufficient growth of the endometrium during ovarian stimulation leads to poor results in in vitro treatment. For this reason, different approaches are used to improve the thickness of the endometrium. One of them is based on the extraction of stem cells and / or active substances and growth factors from the patient’s circulatory system, which after processing and activation are injected into the lining of the uterine body.

This method is successfully used in women with a history of a series of unsuccessful in vitro procedures, thin endometrium, women with a history of chronic endometritis.

What is the treatment?

Before planning the procedure for regeneration of the uterine lining, the patient undergoes the necessary gynecological examinations and tests. A day and time are appointed for the manipulation, before which the patient is given venous blood, for the processing of which it takes between 1 and 2 hours. This is followed by injection of isolated and activated growth factors into the endometrium. The procedure is painless and does not require anesthesia. The effect of the treatment is achieved after 1-3 procedures. Studies show that this approach to treatment significantly improves the chance of pregnancy, and the results are comparable to those in which the lining of the uterus has normal parameters.

There are no contraindications to the use of this method.

1.Therapy for regeneration of ovarian structures2135 BGN
2.Therapy for endometrial regeneration890 BGN