ALICE (Analysis of Infectious Chronic Endometritis)
Infectious chronic endometritis analysis – a method that detects bacteria that cause chronic endometritis, thus improving the chances of pregnancy in patients with reproductive problems.
The uterine cavity is covered with a lining called the endometrium. Endometritis is an inflammation of the lining of the uterus. Depending on the cause of the inflammation, endometritis can be acute or chronic.
The most common causes of endometritis are:
sexually transmitted infections – chlamydia, gonorrhea; tuberculosis – tuberculous mycobacteria reach the uterus through the bloodstream, the primary focus is most often in the lungs; infections arising from the normal vaginal flora that has reached the uterus ascending; intestinal bacteria entering the genitals.
Independent studies show that this disease affects up to 30% of patients with infertility, up to 66% of patients with repeated failed embryo implantation, and in cases of multiple miscarriages.
ALICE is a diagnostic test to detect and quantify the eight most common pathogenic bacteria that cause chronic endometritis, recommending appropriate antibiotic and probiotic treatment.The ALICE microbiological method allows the identification of endometrial pathogens (cultured and uncultivated) associated with chronic endometritis. If the test is positive, the result will be aimed at detecting the specific bacteria causing the condition. Depending on the results of the ALICE test, a list of recommended antibiotics and probiotics is provided.Consultation is also offered.
ALICE can be beneficial for any patient who wishes to become pregnant. It serves to assess the microbiological environment that the embryo will encounter during implantation. ALICE may also be beneficial for patients with a history of multiple miscarriages or recurrent implantation failures due to the established association of chronic endometritis with these cases.
ALICE uses the latest Next Generation Sequencing (NGS) technology to provide microbiometric information from endometrial tissue by analyzing the abundance of specific bacteria that cause chronic endometritis.